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KMID : 0816120070100010071
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Korean Journal of Pediatric Gastroenterolology and Nutrition
2007 Volume.10 No. 1 p.71 ~ p.75
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A Case of Gastrointestinal Stromal Tumor in a Child
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Yun Kyung-Bin
Sul Ji-Young
Kang Dae-Young
Kim Jae-Young
Yu Jae-Hong
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Abstract
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Gastrointestinal stromal tumors (GISTs) are the most common primary mesenchymal tumors of the digestive tract. They have been commonly observed in adults but have been rarely described in children. They arise typically from the intestinal wall and rarely in the mesentery, omentum, or retroperitoneum. GISTs originate from the interstitial cell of Cajal and are characterized by overexpression of the receptor tyrosine kinase c-kit. Up to 94% of these tumors express the CD117 on immunohistochemical stain. Surgery is the main modality of treatment for primary resectable GIST. Completely resectable GIST with low risk has excellent prognosis after primary surgical intervention, with over 90% of the 5-year survival. We report a case of 10-year-old girl presenting with an upper gastrointestinal bleeding caused by gastrointestinal stromal tumor.
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KEYWORD
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Gastrointestinal stromal tumor (GISTs), Interstitial cell of Cajal, Receptor tyrosine Kinase c-kit, CD117, Immunohistochemical stain
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